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A Phylogeny-Based Benchmarking Test for Orthology Inference Reveals the Limitations of Function-Based Validation
Accurate orthology prediction is crucial for many applications in the post-genomic era. The lack of broadly accepted benchmark tests precludes a comprehensive analysis of orthology inference. So far, functional annotation between orthologs serves as a performance proxy. However, this violates the fu...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219706/ https://www.ncbi.nlm.nih.gov/pubmed/25369365 http://dx.doi.org/10.1371/journal.pone.0111122 |