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Foot-and-mouth disease virus leader proteinase: Structural insights into the mechanism of intermolecular cleavage

Translation of foot-and-mouth disease virus RNA initiates at one of two start codons leading to the synthesis of two forms of leader proteinase L(pro) (Lab(pro) and Lb(pro)). These forms free themselves from the viral polyprotein by intra- and intermolecular self-processing and subsequently cleave t...

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Detalles Bibliográficos
Autores principales: Steinberger, Jutta, Grishkovskaya, Irina, Cencic, Regina, Juliano, Luiz, Juliano, Maria A., Skern, Tim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4220004/
https://www.ncbi.nlm.nih.gov/pubmed/25240326
http://dx.doi.org/10.1016/j.virol.2014.08.023