Cargando…

Foot-and-mouth disease virus leader proteinase: Structural insights into the mechanism of intermolecular cleavage

Translation of foot-and-mouth disease virus RNA initiates at one of two start codons leading to the synthesis of two forms of leader proteinase L(pro) (Lab(pro) and Lb(pro)). These forms free themselves from the viral polyprotein by intra- and intermolecular self-processing and subsequently cleave t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Steinberger, Jutta, Grishkovskaya, Irina, Cencic, Regina, Juliano, Luiz, Juliano, Maria A., Skern, Tim
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Academic Press 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4220004/ https://www.ncbi.nlm.nih.gov/pubmed/25240326 http://dx.doi.org/10.1016/j.virol.2014.08.023

Ejemplares similares

Comparison of self-processing of foot-and-mouth disease virus leader proteinase and porcine reproductive and respiratory syndrome virus leader proteinase nsp1α()
por: Steinberger, Jutta, et al.
Publicado: (2013)

Protection of swine by live and inactivated vaccines prepared from a leader proteinase-deficient serotype A12 foot-and-mouth disease virus
por: Chinsangaram, Jarasvech, et al.
Publicado: (1998)

MDA5 cleavage by the Leader protease of foot-and-mouth disease virus reveals its pleiotropic effect against the host antiviral response
por: Pulido, Miguel Rodríguez, et al.
Publicado: (2020)

Expression in Escherichia coli and purification of biologically active L proteinase of foot-and-mouth disease virus
por: Piccone, Maria E., et al.
Publicado: (1995)

Picornaviruses
por: Neubauer, David, et al.
Publicado: (2009)

The DDX23 Negatively Regulates Translation and Replication of Foot-and-Mouth Disease Virus and Is Degraded by 3C Proteinase
por: Abdullah, Sahibzada Waheed, et al.
Publicado: (2020)

Multifunctional roles of leader protein of foot-and-mouth disease viruses in suppressing host antiviral responses
por: Liu, Yingqi, et al.
Publicado: (2015)

Innate immune sensor LGP2 is cleaved by the Leader protease of foot-and-mouth disease virus
por: Rodríguez Pulido, Miguel, et al.
Publicado: (2018)

Foot-and-mouth disease virus induces lysosomal degradation of host protein kinase PKR by 3C proteinase to facilitate virus replication
por: Li, Chuntian, et al.
Publicado: (2017)

Insights into Cleavage Specificity from the Crystal Structure of Foot-and-Mouth Disease Virus 3C Protease Complexed with a Peptide Substrate
por: Zunszain, Patricia A., et al.
Publicado: (2010)

Translation Directed by Hepatitis A Virus IRES in the Absence of Active eIF4F Complex and eIF2
por: Redondo, Natalia, et al.
Publicado: (2012)

Genetic economy in picornaviruses: Foot-and-mouth disease virus replication exploits alternative precursor cleavage pathways
por: Herod, Morgan R., et al.
Publicado: (2017)

An Engineered Maturation Cleavage Provides a Recombinant Mimic of Foot-and-Mouth Disease Virus Capsid Assembly-Disassembly
por: Newman, Joseph, et al.
Publicado: (2021)

NMR analysis of the interaction of picornaviral proteinases Lb and 2A with their substrate eukaryotic initiation factor 4GII
por: Aumayr, Martina, et al.
Publicado: (2015)

Genetic heterogeneity in the leader and P1-coding regions of foot-and-mouth disease virus serotypes A and O in Africa
por: Chitray, M., et al.
Publicado: (2013)

How foot-and-mouth disease virus receptor mediates foot-and-mouth disease virus infection
por: Wang, Guangxiang, et al.
Publicado: (2015)

Coronavirus 3CL(pro )proteinase cleavage sites: Possible relevance to SARS virus pathology
por: Kiemer, Lars, et al.
Publicado: (2004)

Identification and characterization of hippuristanol-resistant mutants reveals eIF4A1 dependencies within mRNA 5′ leader regions
por: Steinberger, Jutta, et al.
Publicado: (2020)

Determinants of the VP1/2A junction cleavage by the 3C protease in foot-and-mouth disease virus-infected cells
por: Kristensen, Thea, et al.
Publicado: (2017)

Foot & mouth disease
Publicado: (2006)

Foot and Mouth Disease
Publicado: (1884)

Foot and Mouth Disease
Publicado: (1892)

Foot-and-Mouth Disease
por: Peters, Austin
Publicado: (1903)

Foot- and Mouth-disease
Publicado: (1897)

Targeting intramolecular proteinase NS2B/3 cleavages for trans-dominant inhibition of dengue virus
por: Constant, David A., et al.
Publicado: (2018)

Potent and Broad but not Unselective Cleavage of Cytokines and Chemokines by Human Neutrophil Elastase and Proteinase 3
por: Fu, Zhirong, et al.
Publicado: (2020)

Computational insights into RNAi-based therapeutics for foot and mouth disease of Bostaurus
por: Sahu, Tanmaya Kumar, et al.
Publicado: (2020)

Development of an in vitro cleavage assay system to examine vaccinia virus I7L cysteine proteinase activity
por: Byrd, Chelsea M, et al.
Publicado: (2005)

Further Requirements for Cleavage by the Murine Coronavirus 3C-like Proteinase: Identification of a Cleavage Site within ORF1b
por: Piñón, Josefina D., et al.
Publicado: (1999)

Structures of foot and mouth disease virus pentamers: Insight into capsid dissociation and unexpected pentamer reassociation
por: Malik, Nayab, et al.
Publicado: (2017)

Single-Cell Sequencing Yields Insights in the Evolution of Foot-and-Mouth Disease Virus Persistent Infection
por: Yuan, Yuncong, et al.
Publicado: (2022)

Insights into Polyprotein Processing and RNA-Protein Interactions in Foot-and-Mouth Disease Virus Genome Replication
por: Pierce, Danielle M., et al.
Publicado: (2023)

Foot-and-Mouth Disease in Massachusetts
por: Peters, Austin
Publicado: (1903)

Analogous Foot-and-Mouth Disease
por: Mills, C. C.
Publicado: (1903)

Transmission Parameters of the 2001 Foot and Mouth Epidemic in Great Britain
por: Chis Ster, Irina, et al.
Publicado: (2007)

Genetic analysis of foot-and-mouth disease virus serotype A of Indian origin and detection of positive selection and recombination in leader protease- and capsid-coding regions
por: Nagendrakumar, S. B., et al.
Publicado: (2009)

Further Characterization of the Coronavirus Infectious Bronchitis Virus 3C-like Proteinase and Determination of a New Cleavage Site
por: Ng, Lisa F.P., et al.
Publicado: (2000)

Foot-and-Mouth Disease Virus Serotype A in Egypt
por: Knowles, Nick J., et al.
Publicado: (2007)

Characterization of epitope-tagged foot-and-mouth disease virus
por: Seago, Julian, et al.
Publicado: (2012)

The pH stability of foot-and-mouth disease virus
por: Yuan, Hong, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_r7k2trildofhar7oodpo9vpg36