Anti-hyperalgesic effects of a novel TRPM8 agonist in neuropathic rats: A comparison with topical menthol

Menthol has historically been used topically to alleviate various pain conditions. At low concentrations, this non-selective TRPM8 agonist elicits a cooling sensation, however higher concentrations result in cold hyperalgesia in normal subjects and paradoxically analgesia in neuropathic patients. Th...

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Detalles Bibliográficos
Autores principales: Patel, Ryan, Gonçalves, Leonor, Leveridge, Mathew, Mack, Stephen R., Hendrick, Alan, Brice, Nicola L., Dickenson, Anthony H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4220012/
https://www.ncbi.nlm.nih.gov/pubmed/25083927
http://dx.doi.org/10.1016/j.pain.2014.07.022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4220012/
https://www.ncbi.nlm.nih.gov/pubmed/25083927
http://dx.doi.org/10.1016/j.pain.2014.07.022

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