Exploring nicotinamide cofactor promiscuity in NAD(P)H-dependent flavin containing monooxygenases (FMOs) using natural variation within the phosphate binding loop. Structure and activity of FMOs from Cellvibrio sp. BR and Pseudomonas stutzeri NF13

Flavin-containing monooxygenases (FMOs) catalyse asymmetric oxidation reactions that have potential for preparative organic synthesis, but most use the more expensive, phosphorylated nicotinamide cofactor NADPH to reduce FAD to FADH(2) prior to formation of the (hydro)peroxy intermediate required fo...

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Detalles Bibliográficos
Autores principales: Jensen, Chantel N., Ali, Sohail T., Allen, Michael J., Grogan, Gideon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4220118/
https://www.ncbi.nlm.nih.gov/pubmed/25383040
http://dx.doi.org/10.1016/j.molcatb.2014.08.019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4220118/
https://www.ncbi.nlm.nih.gov/pubmed/25383040
http://dx.doi.org/10.1016/j.molcatb.2014.08.019

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