Small Bifunctional Chelators That Do Not Disaggregate Amyloid β Fibrils Exhibit Reduced Cellular Toxicity

[Image: see text] Multifunctional metal chelators that can modulate the amyloid β (Aβ) peptide aggregation and its interaction with metal ions such as copper and zinc hold considerable promise as therapeutic agents for Alzheimer’s disease (AD). However, specific rather than systemic metal chelation...

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Detalles Bibliográficos
Autores principales: Sharma, Anuj K., Kim, Jaekwang, Prior, John T., Hawco, Nicholas J., Rath, Nigam P., Kim, Jungsu, Mirica, Liviu M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4220862/
https://www.ncbi.nlm.nih.gov/pubmed/25333939
http://dx.doi.org/10.1021/ic500926c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4220862/
https://www.ncbi.nlm.nih.gov/pubmed/25333939
http://dx.doi.org/10.1021/ic500926c

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