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Small Bifunctional Chelators That Do Not Disaggregate Amyloid β Fibrils Exhibit Reduced Cellular Toxicity
[Image: see text] Multifunctional metal chelators that can modulate the amyloid β (Aβ) peptide aggregation and its interaction with metal ions such as copper and zinc hold considerable promise as therapeutic agents for Alzheimer’s disease (AD). However, specific rather than systemic metal chelation...
Autores principales: | Sharma, Anuj K., Kim, Jaekwang, Prior, John T., Hawco, Nicholas J., Rath, Nigam P., Kim, Jungsu, Mirica, Liviu M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4220862/ https://www.ncbi.nlm.nih.gov/pubmed/25333939 http://dx.doi.org/10.1021/ic500926c |
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