Cargando…

Docking study of novel antihyperlipidemic thieno[2,3-d]pyrimidine; LM-1554, with some molecular targets related to hyperlipidemia - an investigation into its mechanism of action

An investigation into the mechanism of antihyperlipidemic action of 2-chloromethyl-5,6,7,8-tetrahydrobenzo(b)thieno[2,3-d]pyrimidin-4(3H)-one (LM-1554) was carried out through docking experiments with six different molecular targets; Niemann Pick C1 Like1 protein (NPC1L1), ATP citrate lyase (ACL), C...

Descripción completa

Detalles Bibliográficos
Autores principales:	Khedkar, Vijay M, Arya, Nikhilesh, Coutinho, Evans C, Shishoo, Chamanlal J, Jain, Kishor S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4221561/ https://www.ncbi.nlm.nih.gov/pubmed/25392798 http://dx.doi.org/10.1186/2193-1801-3-628

Ejemplares similares

Pharmacokinetic Study of a Novel Antihyperlipidemic Agent LM-13765- A Prodrug
por: Shah, T. M., et al.
Publicado: (2009)

Synthesis, Characterization and Biological Studies of Some Novel Thieno[2,3-d]pyrimidines
por: Al-Taisan, Khulud M., et al.
Publicado: (2010)

Design, synthesis, docking, MD simulations, and anti-proliferative evaluation of thieno[2,3-d]pyrimidine derivatives as new EGFR inhibitors
por: Sobh, Eman A., et al.
Publicado: (2023)

Design, synthesis, anti-proliferative evaluation, docking, and MD simulation studies of new thieno[2,3-d]pyrimidines targeting VEGFR-2
por: El-Metwally, Souad A., et al.
Publicado: (2023)

A Simple Synthesis of Some New Thienopyridine and Thieno-pyrimidine Derivatives
por: El-Saghier, Ahmed M. M.
Publicado: (2002)

México en 1554
por: Cervantes de Salazar, Francisco, aproximadamente 1514-aproximadamente 1575
Publicado: (2002)

México en 1554
por: Cervantes de Salazar, Francisco, aproximadamente 1514-aproximadamente 1575
Publicado: (1939)

México en 1554
por: Cervantes de Salazar, Francisco, aproximadamente 1514-aproximadamente 1575
Publicado: (1952)

México en 1554
por: Cervantes de Salazar, Francisco, aproximadamente 1514-aproximadamente 1575
Publicado: (1964)

1554 México 2012/
por: Cervantes, de Salazar Francisco

México en 1554
por: Cervantes de Salazar, Francisco, aproximadamente 1514-aproximadamente 1575
Publicado: (1973)

3,5,6-Trimethylthieno[2,3-d]pyrimidin-4(3H)-one
por: Khatamov, Khamroqul, et al.
Publicado: (2012)

Identification of 4-Amino-Thieno[2,3-d]Pyrimidines as QcrB Inhibitors in Mycobacterium tuberculosis
por: Harrison, Gregory A., et al.
Publicado: (2019)

México en 1554 ; y Túmulo imperial
por: Cervantes de Salazar, Francisco, aproximadamente 1514-aproximadamente 1575
Publicado: (1963)

Investigation of microemulsion system for transdermal delivery of itraconazole
por: Chudasama, Arpan, et al.
Publicado: (2011)

Design, synthesis, and biological evaluation of pyrido[2,3-d]pyrimidine and thieno[2,3-d]pyrimidine derivatives as novel EGFR(L858R/T790M) inhibitors
por: Fu, Jianfang, et al.
Publicado: (2023)

Antihyperlipidemic potential of diosmin in Swiss Albino mice with high-fat diet induced hyperlipidemia
por: Firdous, Sayeed Mohammed, et al.
Publicado: (2021)

México en 1554 : tres diálogos latinos que Francisco Cervántes Salazar
por: Cervantes de Salazar, Francisco, aproximadamente 1514-aproximadamente 1575
Publicado: (2001)

N-Benzylthieno[3,2-d]pyrimidin-4-amine
por: Štarha, Pavel, et al.
Publicado: (2013)

Design, Synthesis, and Biological Activity of Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine Derivatives as Anti-Inflammatory Agents
por: Zhang, Yuan, et al.
Publicado: (2017)

7-Methyl-5,6,7,8-tetrahydro-1-benzothieno[2,3-d]pyrimidin-4-amine
por: Ziaulla, Mohamed, et al.
Publicado: (2011)

Pyridine-Based Heterocycles. Synthesis of New Pyrido [4',3':4,5]thieno[2,3-d]pyrimidines and Related Heterocycles
por: El-Kashef, Hussein, et al.
Publicado: (2010)

Synthesis of Novel Analogs of Thieno[2,3-d] Pyrimidin-4(3H)-ones as Selective Inhibitors of Cancer Cell Growth
por: Zhang, Sheng, et al.
Publicado: (2019)

2-Alkyl-Substituted-4-Amino-Thieno[2,3-d]Pyrimidines: Anti-Proliferative Properties to In Vitro Breast Cancer Models
por: Iliev, Ivan, et al.
Publicado: (2023)

Synthesis, characterization and in vitro antimicrobial activity of novel fused pyrazolo[3,4-c]pyridazine, pyrazolo[3,4-d]pyrimidine, thieno[3,2-c]pyrazole and pyrazolo[3′,4′:4,5]thieno[2,3-d]pyrimidine derivatives
por: Abdel Reheim, Mohamed A. M., et al.
Publicado: (2017)

Pharmacological Screening of Trachyspermum ammi for Antihyperlipidemic Activity in Triton X-100 Induced Hyperlipidemia Rat Model
por: Saleem, Uzma, et al.
Publicado: (2017)

In Vitro and In Vivo Anti-Breast Cancer Activities of Some Newly Synthesized 5-(thiophen-2-yl)thieno-[2,3-d]pyrimidin-4-one Candidates
por: Amr, Abd El-Galil E., et al.
Publicado: (2019)

Armonía y contradicciones cubano-mexicanas (1554-1830) /
por: Franco, José Luciano, 1891-
Publicado: (1975)

Sir William Paddy , M.D. (1554-1634).
por: Pady, D S
Publicado: (1974)

Correction to: Synthesis, characterization and in vitro antimicrobial activity of novel fused pyrazolo[3,4-c]pyridazine, pyrazolo[3,4-d]pyrimidine, thieno[3,2-c] pyrazole and pyrazolo[3′,4′:4,5]thieno[2,3-d]pyrimidine derivatives
por: Abdel Reheim, Mohamed A. M., et al.
Publicado: (2017)

2-Phenylthieno[2,3-b]quinoxaline
por: Ramli, Youssef, et al.
Publicado: (2012)

4-Substituted Thieno[3,2-d]pyrimidines as Dual-Stage Antiplasmodial Derivatives
por: Lagardère, Prisca, et al.
Publicado: (2022)

Synthesis, Bioactivity, Molecular Docking and POM Analyses of Novel Substituted Thieno[2,3-b]thiophenes and Related Congeners
por: Mabkhot, Yahia N., et al.
Publicado: (2015)

Synthesis, Antitumor Activity, and Docking Analysis of New Pyrido[3′,2′:4,5]furo(thieno)[3,2-d]pyrimidin-8-amines
por: Sirakanyan, Samvel N., et al.
Publicado: (2019)

Synthesis and Antimicrobial Activity of Some New Thieno[2,3-b]thiophene Derivatives
por: Mabkhot, Yahia Nasser, et al.
Publicado: (2013)

2,3-Trimethylene-7,8-dihydropyrrolo[1,2-a]thieno[2,3-d]pyrimidin-4(6H)-one
por: Bozorov, Khurshed, et al.
Publicado: (2013)

Design, synthesis, and biological evaluation of new thieno[2,3-d] pyrimidine derivatives as targeted therapy for PI3K with molecular modelling study
por: Elmenier, Fatma M., et al.
Publicado: (2021)

Design, Synthesis, and Biological Evaluation of 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidines as Microtubule Targeting Agents
por: Islam, Farhana, et al.
Publicado: (2022)

Tu1554: A NOVEL METHOD FOR COLLECTING MICROBIOME SPECIMENS
por: Rahimian, Pejman, et al.
Publicado: (2022)

Human immunodeficiency virus type 1 transcription is regulated by thieno[3,4-d]pyrimidine
por: Xu, Wenfang, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_pn0165hegni5n91ceqrsqcq061