Efficient transduction of LEDGF/p75 mutant cells by complementary gain-of-function HIV-1 integrase mutant viruses

Controlling the specificity of retroviral DNA integration could improve the safety of gene therapy vectors, and fusions of heterologous chromatin binding modules to the integrase (IN)–binding domain from the lentiviral integration host cofactor lens epithelium–derived growth factor (LEDGF)/p75 are a...

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Detalles Bibliográficos
Autores principales: Wang, Hao, Shun, Ming-Chieh, Li, Xiang, Di Nunzio, Francesca, Hare, Stephen, Cherepanov, Peter, Engelman, Alan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222252/
https://www.ncbi.nlm.nih.gov/pubmed/25383358
http://dx.doi.org/10.1038/mtm.2013.2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222252/
https://www.ncbi.nlm.nih.gov/pubmed/25383358
http://dx.doi.org/10.1038/mtm.2013.2

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