Hydrogen–Deuterium Exchange and Mass Spectrometry Reveal the pH-Dependent Conformational Changes of Diphtheria Toxin T Domain

[Image: see text] The translocation (T) domain of diphtheria toxin plays a critical role in moving the catalytic domain across the endosomal membrane. Translocation/insertion is triggered by a decrease in pH in the endosome where conformational changes of T domain occur through several kinetic inter...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Jing, Rodnin, Mykola V., Ladokhin, Alexey S., Gross, Michael L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222528/
https://www.ncbi.nlm.nih.gov/pubmed/25290210
http://dx.doi.org/10.1021/bi500893y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222528/
https://www.ncbi.nlm.nih.gov/pubmed/25290210
http://dx.doi.org/10.1021/bi500893y

Ejemplares similares