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Hydrogen–Deuterium Exchange and Mass Spectrometry Reveal the pH-Dependent Conformational Changes of Diphtheria Toxin T Domain

[Image: see text] The translocation (T) domain of diphtheria toxin plays a critical role in moving the catalytic domain across the endosomal membrane. Translocation/insertion is triggered by a decrease in pH in the endosome where conformational changes of T domain occur through several kinetic inter...

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Detalles Bibliográficos
Autores principales:	Li, Jing, Rodnin, Mykola V., Ladokhin, Alexey S., Gross, Michael L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222528/ https://www.ncbi.nlm.nih.gov/pubmed/25290210 http://dx.doi.org/10.1021/bi500893y

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