Probing the Origins of Catalytic Discrimination between Phosphate and Sulfate Monoester Hydrolysis: Comparative Analysis of Alkaline Phosphatase and Protein Tyrosine Phosphatases

[Image: see text] Catalytic promiscuity, the ability of enzymes to catalyze multiple reactions, provides an opportunity to gain a deeper understanding of the origins of catalysis and substrate specificity. Alkaline phosphatase (AP) catalyzes both phosphate and sulfate monoester hydrolysis reactions...

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Detalles Bibliográficos
Autores principales: Andrews, Logan D., Zalatan, Jesse G., Herschlag, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222534/
https://www.ncbi.nlm.nih.gov/pubmed/25299936
http://dx.doi.org/10.1021/bi500765p

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222534/
https://www.ncbi.nlm.nih.gov/pubmed/25299936
http://dx.doi.org/10.1021/bi500765p

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