Cargando…

Probing BoNT/A Protease Exosites: Implications for Inhibitor Design and Light Chain Longevity

[Image: see text] Botulinum neurotoxin serotype A (BoNT/A) is one of the most lethal toxins known. Its extreme toxicity is due to its light chain (LC), a zinc protease that cleaves SNAP-25, a synaptosome-associated protein, leading to the inhibition of neuronal activity. Studies on BoNT/A LC have re...

Descripción completa

Detalles Bibliográficos
Autores principales: Xue, Song, Javor, Sacha, Hixon, Mark S., Janda, Kim D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222541/
https://www.ncbi.nlm.nih.gov/pubmed/25295706
http://dx.doi.org/10.1021/bi500950x