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Probing BoNT/A Protease Exosites: Implications for Inhibitor Design and Light Chain Longevity
[Image: see text] Botulinum neurotoxin serotype A (BoNT/A) is one of the most lethal toxins known. Its extreme toxicity is due to its light chain (LC), a zinc protease that cleaves SNAP-25, a synaptosome-associated protein, leading to the inhibition of neuronal activity. Studies on BoNT/A LC have re...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American
Chemical Society
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222541/ https://www.ncbi.nlm.nih.gov/pubmed/25295706 http://dx.doi.org/10.1021/bi500950x |