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Probing BoNT/A Protease Exosites: Implications for Inhibitor Design and Light Chain Longevity

[Image: see text] Botulinum neurotoxin serotype A (BoNT/A) is one of the most lethal toxins known. Its extreme toxicity is due to its light chain (LC), a zinc protease that cleaves SNAP-25, a synaptosome-associated protein, leading to the inhibition of neuronal activity. Studies on BoNT/A LC have re...

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Detalles Bibliográficos
Autores principales:	Xue, Song, Javor, Sacha, Hixon, Mark S., Janda, Kim D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222541/ https://www.ncbi.nlm.nih.gov/pubmed/25295706 http://dx.doi.org/10.1021/bi500950x

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