Approximation to the Distribution of Fitness Effects across Functional Categories in Human Segregating Polymorphisms

Quantifying the proportion of polymorphic mutations that are deleterious or neutral is of fundamental importance to our understanding of evolution, disease genetics and the maintenance of variation genome-wide. Here, we develop an approximation to the distribution of fitness effects (DFE) of segrega...

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Detalles Bibliográficos
Autores principales: Racimo, Fernando, Schraiber, Joshua G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222666/
https://www.ncbi.nlm.nih.gov/pubmed/25375159
http://dx.doi.org/10.1371/journal.pgen.1004697