Approximation to the Distribution of Fitness Effects across Functional Categories in Human Segregating Polymorphisms
Quantifying the proportion of polymorphic mutations that are deleterious or neutral is of fundamental importance to our understanding of evolution, disease genetics and the maintenance of variation genome-wide. Here, we develop an approximation to the distribution of fitness effects (DFE) of segrega...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Public Library of Science
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222666/ https://www.ncbi.nlm.nih.gov/pubmed/25375159 http://dx.doi.org/10.1371/journal.pgen.1004697 |