Targeting Cdc42 with the small molecule drug AZA197 suppresses primary colon cancer growth and prolongs survival in a preclinical mouse xenograft model by downregulation of PAK1 activity

BACKGROUND: Rho GTPases play important roles in cytoskeleton organization, cell cycle progression and are key regulators of tumor progression. Strategies to modulate increased Rho GTPase activities during cancer progression could have therapeutic potential. METHODS: We report here the characterizati...

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Detalles Bibliográficos
Autores principales: Zins, Karin, Gunawardhana, Sandun, Lucas, Trevor, Abraham, Dietmar, Aharinejad, Seyedhossein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222769/
https://www.ncbi.nlm.nih.gov/pubmed/24279335
http://dx.doi.org/10.1186/1479-5876-11-295

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222769/
https://www.ncbi.nlm.nih.gov/pubmed/24279335
http://dx.doi.org/10.1186/1479-5876-11-295

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