Structure and Mechanism of Action of the BRCA2 Breast Cancer Tumor Suppressor

Mutations in BRCA2 increase susceptibility to breast, ovarian and prostate cancers. The product of human BRCA2, BRCA2 protein, plays a key role in the repair of DNA double strand breaks and interstrand crosslinks by RAD51-mediated homologous recombination. Here, we present a biochemical and structur...

Descripción completa

Detalles Bibliográficos
Autores principales: Shahid, Taha, Soroka, Joanna, Kong, Eric, Malivert, Laurent, McIlwraith, Michael J., Pape, Tillman, West, Stephen C., Zhang, Xiaodong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222816/
https://www.ncbi.nlm.nih.gov/pubmed/25282148
http://dx.doi.org/10.1038/nsmb.2899

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222816/
https://www.ncbi.nlm.nih.gov/pubmed/25282148
http://dx.doi.org/10.1038/nsmb.2899

Ejemplares similares