A Functional Approach Reveals a Genetic and Physical Interaction between Ribonucleotide Reductase and CHK1 in Mammalian Cells

Ribonucleotide reductase (RNR) enzyme is composed of the homodimeric RRM1 and RRM2 subunits, which together form a heterotetramic active enzyme that catalyzes the de novo reduction of ribonucleotides to generate deoxyribonucleotides (dNTPs), which are required for DNA replication and DNA repair proc...

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Detalles Bibliográficos
Autores principales: Taricani, Lorena, Shanahan, Frances, Malinao, Maria-Christina, Beaumont, Maribel, Parry, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222937/
https://www.ncbi.nlm.nih.gov/pubmed/25375241
http://dx.doi.org/10.1371/journal.pone.0111714

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222937/
https://www.ncbi.nlm.nih.gov/pubmed/25375241
http://dx.doi.org/10.1371/journal.pone.0111714

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