A Critical Residue Selectively Recruits Nucleotides for T7 RNA Polymerase Transcription Fidelity Control

Nucleotide selection is essential for fidelity control in gene replication and transcription. Recent work on T7 RNA polymerase suggested that a small posttranslocation free energy bias stabilizes Tyr(639) in the active site to aid nucleotide selection. However, it was not clear exactly how Tyr(639)...

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Detalles Bibliográficos
Autores principales: Duan, Baogen, Wu, Shaogui, Da, Lin-Tai, Yu, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Biophysical Society 2014
Materias:
Molecular Machines, Motors and Nanoscale Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223216/
https://www.ncbi.nlm.nih.gov/pubmed/25418098
http://dx.doi.org/10.1016/j.bpj.2014.09.038

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223216/
https://www.ncbi.nlm.nih.gov/pubmed/25418098
http://dx.doi.org/10.1016/j.bpj.2014.09.038

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