Kinesin-5 Allosteric Inhibitors Uncouple the Dynamics of Nucleotide, Microtubule, and Neck-Linker Binding Sites

Kinesin motor domains couple cycles of ATP hydrolysis to cycles of microtubule binding and conformational changes that result in directional force and movement on microtubules. The general principles of this mechanochemical coupling have been established; however, fundamental atomistic details of th...

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Detalles Bibliográficos
Autores principales: Scarabelli, Guido, Grant, Barry J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Biophysical Society 2014
Materias:
Proteins and Nucleic Acids
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223232/
https://www.ncbi.nlm.nih.gov/pubmed/25418105
http://dx.doi.org/10.1016/j.bpj.2014.09.019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223232/
https://www.ncbi.nlm.nih.gov/pubmed/25418105
http://dx.doi.org/10.1016/j.bpj.2014.09.019

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