Interaction of the Molecular Chaperone DNAJB6 with Growing Amyloid-beta 42 (Aβ42) Aggregates Leads to Sub-stoichiometric Inhibition of Amyloid Formation

The human molecular chaperone protein DNAJB6 was recently found to inhibit the formation of amyloid fibrils from polyglutamine peptides associated with neurodegenerative disorders such as Huntington disease. We show in the present study that DNAJB6 also inhibits amyloid formation by an even more agg...

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Detalles Bibliográficos
Autores principales: Månsson, Cecilia, Arosio, Paolo, Hussein, Rasha, Kampinga, Harm H., Hashem, Reem M., Boelens, Wilbert C., Dobson, Christopher M., Knowles, Tuomas P. J., Linse, Sara, Emanuelsson, Cecilia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223311/
https://www.ncbi.nlm.nih.gov/pubmed/25217638
http://dx.doi.org/10.1074/jbc.M114.595124

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223311/
https://www.ncbi.nlm.nih.gov/pubmed/25217638
http://dx.doi.org/10.1074/jbc.M114.595124

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