PINK1-mediated Phosphorylation of Miro Inhibits Synaptic Growth and Protects Dopaminergic Neurons in Drosophila

Mutations in the mitochondrial Ser/Thr kinase PINK1 cause Parkinson's disease. One of the substrates of PINK1 is the outer mitochondrial membrane protein Miro, which regulates mitochondrial transport. In this study, we uncovered novel physiological functions of PINK1-mediated phosphorylation of...

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Detalles Bibliográficos
Autores principales: Tsai, Pei-I, Course, Meredith M., Lovas, Jonathan R., Hsieh, Chung-Han, Babic, Milos, Zinsmaier, Konrad E., Wang, Xinnan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223694/
https://www.ncbi.nlm.nih.gov/pubmed/25376463
http://dx.doi.org/10.1038/srep06962

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223694/
https://www.ncbi.nlm.nih.gov/pubmed/25376463
http://dx.doi.org/10.1038/srep06962

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