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Hypoxia represses microRNA biogenesis proteins in breast cancer cells

BACKGROUND: Cancers are commonly characterised by hypoxia and also by global reductions in the levels of mature microRNAs. We have examined the hypothesis that hypoxia might mediate this reduction through repressive effects on microRNA biogenesis proteins. METHODS: Breast cancer cell lines were expo...

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Detalles Bibliográficos
Autores principales: Bandara, Veronika, Michael, Michael Z, Gleadle, Jonathan M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223767/
https://www.ncbi.nlm.nih.gov/pubmed/25052766
http://dx.doi.org/10.1186/1471-2407-14-533