In Silico Prediction of Synthetic Lethality by Meta-Analysis of Genetic Interactions, Functions, and Pathways in Yeast and Human Cancer

A major goal in cancer medicine is to find selective drugs with reduced side effect. A pair of genes is called synthetic lethality (SL) if mutations of both genes will kill a cell while mutation of either gene alone will not. Hence, a gene in SL interactions with a cancer-specific mutated gene will...

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Detalles Bibliográficos
Autores principales: Wu, Min, Li, Xuejuan, Zhang, Fan, Li, Xiaoli, Kwoh, Chee-Keong, Zheng, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Libertas Academica 2014
Materias:
Methodology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224103/
https://www.ncbi.nlm.nih.gov/pubmed/25452682
http://dx.doi.org/10.4137/CIN.S14026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224103/
https://www.ncbi.nlm.nih.gov/pubmed/25452682
http://dx.doi.org/10.4137/CIN.S14026

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