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Platelets Direct Monocyte Differentiation Into Epithelioid-Like Multinucleated Giant Foam Cells With Suppressive Capacity Upon Mycobacterial Stimulation
Background. Epithelioid, foam, and multinucleated giant cells (MNGCs) are characteristics of tuberculosis granulomas, yet the precise genesis and functions of these transformed macrophages are unclear. We evaluated the role of platelets as drivers of macrophage transformation in mycobacterial infect...
Autores principales: | Feng, Yonghong, Dorhoi, Anca, Mollenkopf, Hans-Joachim, Yin, Hongyun, Dong, Zhengwei, Mao, Ling, Zhou, Jun, Bi, Aixiao, Weber, Stephan, Maertzdorf, Jeroen, Chen, Gang, Chen, Yang, Kaufmann, Stefan H. E. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224136/ https://www.ncbi.nlm.nih.gov/pubmed/24987031 http://dx.doi.org/10.1093/infdis/jiu355 |
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