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Conservation Weighting Functions Enable Covariance Analyses to Detect Functionally Important Amino Acids
The explosive growth in the number of protein sequences gives rise to the possibility of using the natural variation in sequences of homologous proteins to find residues that control different protein phenotypes. Because in many cases different phenotypes are each controlled by a group of residues,...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224327/ https://www.ncbi.nlm.nih.gov/pubmed/25379728 http://dx.doi.org/10.1371/journal.pone.0107723 |