Differential Effect of HDAC3 on Cytoplasmic and Nuclear Huntingtin Aggregates

Histone deacetylases (HDACs) are potential therapeutic targets of polyglutamine (pQ) diseases including Huntington’s disease (HD) that may function to correct aberrant transcriptional deactivation caused by mutant pQ proteins. HDAC3 is a unique class 1 HDAC found in both the cytoplasm and in the nuc...

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Detalles Bibliográficos
Autores principales: Mano, Tatsuo, Suzuki, Takayoshi, Tsuji, Shoji, Iwata, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224383/
https://www.ncbi.nlm.nih.gov/pubmed/25380050
http://dx.doi.org/10.1371/journal.pone.0111277

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224383/
https://www.ncbi.nlm.nih.gov/pubmed/25380050
http://dx.doi.org/10.1371/journal.pone.0111277

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