Cargando…

Elongation factor-2 kinase regulates TG2/β1 integrin/Src/uPAR pathway and epithelial–mesenchymal transition mediating pancreatic cancer cells invasion

Pancreatic ductal adenocarcinoma is one of the lethal cancers with extensive local tumour invasion, metastasis, early systemic dissemination and poorest prognosis. Thus, understanding the mechanisms regulating invasion/metastasis and epithelial–mesenchymal transition (EMT), is the key for developing...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ashour, Ahmed A, Gurbuz, Nilgun, Alpay, Sultan Neslihan, Abdel-Aziz, Abdel-Aziz H, Mansour, Ahmed M, Huo, Longfei, Ozpolat, Bulent
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2014
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224557/ https://www.ncbi.nlm.nih.gov/pubmed/25215932 http://dx.doi.org/10.1111/jcmm.12361

Ejemplares similares

Down-Regulation of 5-HT(1B) and 5-HT(1D) Receptors Inhibits Proliferation, Clonogenicity and Invasion of Human Pancreatic Cancer Cells
por: Gurbuz, Nilgun, et al.
Publicado: (2014)

Integrin is on uPAR to unleash cells
por: LeBrasseur, Nicole
Publicado: (2003)

Data on the regulation of moesin and merlin by the urokinase receptor (uPAR): Model explaining distal activation of integrins by uPAR
por: Degryse, Bernard, et al.
Publicado: (2017)

FOXM1 regulates expression of eukaryotic elongation factor 2 kinase and promotes proliferation, invasion and tumorgenesis of human triple negative breast cancer cells
por: Hamurcu, Zuhal, et al.
Publicado: (2016)

Integrin-uPAR signaling leads to FRA-1 phosphorylation and enhanced breast cancer invasion
por: Annis, Matthew G., et al.
Publicado: (2018)

uPAR's signaling two step
por: Leslie, Mitch
Publicado: (2007)

uPAR: An Essential Factor for Tumor Development
por: Lv, Tao, et al.
Publicado: (2021)

Secreted uPAR isoform 2 (uPAR7b) is a novel direct target of miR-221
por: Falkenberg, Natalie, et al.
Publicado: (2015)

Identification of a New Epitope in uPAR as a Target for the Cancer Therapeutic Monoclonal Antibody ATN-658, a Structural Homolog of the uPAR Binding Integrin CD11b (αM)
por: Xu, Xiang, et al.
Publicado: (2014)

Correction: Identification of a New Epitope in uPAR as a Target for the Cancer Therapeutic Monoclonal Antibody ATN-658, a Structural Homolog of the uPAR Binding Integrin CD11b (αM)
Publicado: (2014)

Correction: Identification of a New Epitope in uPAR as a Target for the Cancer Therapeutic Monoclonal Antibody ATN-658, a Structural Homolog of the uPAR Binding Integrin CD11b (αM)
Publicado: (2014)

uPAR directed-imaging of head-and-neck cancer
por: Baart,, Victor M., et al.
Publicado: (2017)

Crystal structure and cellular functions of uPAR dimer
por: Yu, Shujuan, et al.
Publicado: (2022)

Retraction: uPAR/Cathepsin B Overexpression Reverse Angiogenesis by Rescuing FAK Phosphorylation in uPAR/Cathepsin B Down Regulated Meningioma
Publicado: (2020)

Suppression of uPAR Retards Radiation-Induced Invasion and Migration Mediated by Integrin β1/FAK Signaling in Medulloblastoma
por: Nalla, Arun Kumar, et al.
Publicado: (2010)

Targeted Silencing of Elongation Factor 2 Kinase Suppresses Growth and Sensitizes Tumors to Doxorubicin in an Orthotopic Model of Breast Cancer
por: Tekedereli, Ibrahim, et al.
Publicado: (2012)

A doxycycline-inducible urokinase receptor (uPAR) upregulates uPAR activities including resistance to anoikis in human prostate cancer cell lines
por: Hasanuzzaman, Mohammad, et al.
Publicado: (2007)

uPAR and cathepsin B knockdown inhibits radiation-induced PKC integrated integrin signaling to the cytoskeleton of glioma-initiating cells
por: ALAPATI, KIRANMAI, et al.
Publicado: (2012)

The Urokinase Receptor (uPAR) Facilitates Clearance of Borrelia burgdorferi
por: Hovius, Joppe W. R., et al.
Publicado: (2009)

MMP-9 and uPAR regulated glioma cell migration
por: Veeravalli, Krishna Kumar, et al.
Publicado: (2012)

Characterization and function of human Ly-6/uPAR molecules
por: Kong, Hyun Kyung, et al.
Publicado: (2012)

First-in-human uPAR PET: Imaging of Cancer Aggressiveness
por: Persson, Morten, et al.
Publicado: (2015)

Expression of uPAR in Urinary Podocytes of Patients with Fabry Disease
por: Trimarchi, Hernán, et al.
Publicado: (2017)

The uPA/uPAR system in astrocytic wound healing
por: Yepes, Manuel
Publicado: (2022)

uPAR-expressing melanoma exosomes promote angiogenesis by VE-Cadherin, EGFR and uPAR overexpression and rise of ERK1,2 signaling in endothelial cells
por: Biagioni, Alessio, et al.
Publicado: (2020)

MMP-9, uPAR and Cathepsin B Silencing Downregulate Integrins in Human Glioma Xenograft Cells In Vitro and In Vivo in Nude Mice
por: Veeravalli, Krishna Kumar, et al.
Publicado: (2010)

Clathrin and LRP-1-Independent Constitutive Endocytosis and Recycling of uPAR
por: Cortese, Katia, et al.
Publicado: (2008)

uPAR-induced cell adhesion and migration: vitronectin provides the key
por: Madsen, Chris D., et al.
Publicado: (2007)

Prognostic value of uPAR expression and angiogenesis in primary and metastatic melanoma
por: Hugdahl, Emilia, et al.
Publicado: (2019)

The uPAR System as a Potential Therapeutic Target in the Diseased Eye
por: Cammalleri, Maurizio, et al.
Publicado: (2019)

New Pieces in the Puzzle of uPAR Role in Cell Migration Mechanisms
por: Gorrasi, Anna, et al.
Publicado: (2020)

Identification of uPAR Variants Acting as ceRNAs in Leukaemia Cells
por: Alfieri, Mariaevelina, et al.
Publicado: (2022)

Orientational Preferences of GPI-Anchored Ly6/uPAR Proteins
por: Zaigraev, Maxim M., et al.
Publicado: (2022)

Downregulation of urokinase plasminogen activator receptor expression inhibits Erk signalling with concomitant suppression of invasiveness due to loss of uPAR–β1 integrin complex in colon cancer cells
por: Ahmed, N, et al.
Publicado: (2003)

The blocking of uPAR suppresses lipopolysaccharide‐induced inflammatory osteoclastogenesis and the resultant bone loss through attenuation of integrin β3/Akt pathway
por: Kanno, Yosuke, et al.
Publicado: (2016)

uPAR antibody (huATN-658) and Zometa reduce breast cancer growth and skeletal lesions
por: Mahmood, Niaz, et al.
Publicado: (2020)

Degradation of Internalized αvβ5 Integrin Is Controlled by uPAR Bound uPA: Effect on β1 Integrin Activity and α-SMA Stress Fiber Assembly
por: Wang, Lingyan, et al.
Publicado: (2012)

Identification of uPAR-positive Chemoresistant Cells in Small Cell Lung Cancer
por: Gutova, Margarita, et al.
Publicado: (2007)

uPAR induces epithelial–mesenchymal transition in hypoxic breast cancer cells
por: Lester, Robin D., et al.
Publicado: (2007)

A deficiency of uPAR alters endothelial angiogenic function and cell morphology
por: Balsara, Rashna D, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_qnbce2i3evfpo1vlsqo1ghquc4