Peptidomimetic inhibitors of N-myristoyltransferase from human malaria and leishmaniasis parasites

N-Myristoyltransferase (NMT) has been shown to be essential in Leishmania and subsequently validated as a drug target in Plasmodium. Herein, we discuss the use of antifungal NMT inhibitors as a basis for inhibitor development resulting in the first sub-micromolar peptidomimetic inhibitors of Plasmod...

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Detalles Bibliográficos
Autores principales: Olaleye, Tayo O., Brannigan, James A., Roberts, Shirley M., Leatherbarrow, Robin J., Wilkinson, Anthony J., Tate, Edward W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2014
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224572/
https://www.ncbi.nlm.nih.gov/pubmed/25230674
http://dx.doi.org/10.1039/c4ob01669f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224572/
https://www.ncbi.nlm.nih.gov/pubmed/25230674
http://dx.doi.org/10.1039/c4ob01669f

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