Cerebrospinal-fluid exposure of efavirenz and its major metabolites when dosed at 400 and 600 mg once daily; a randomized controlled trial

INTRODUCTION: The optimal penetration of antiretroviral agents into central nervous system (CNS) may be a balance between providing adequate drug exposure to inhibit HIV-replication whilst avoiding concentrations associated with toxicities. METHODS: Cerebrospinal-fluid (CSF) exposure of efavirenz an...

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Detalles Bibliográficos
Autores principales: Winston, Alan, and Puls, Rebekah, CSF Sub-study, group Encore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International AIDS Society 2014
Materias:
Poster Sessions – Abstract P050
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224808/
https://www.ncbi.nlm.nih.gov/pubmed/25394049
http://dx.doi.org/10.7448/IAS.17.4.19541

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224808/
https://www.ncbi.nlm.nih.gov/pubmed/25394049
http://dx.doi.org/10.7448/IAS.17.4.19541

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