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Cerebrospinal-fluid exposure of efavirenz and its major metabolites when dosed at 400 and 600 mg once daily; a randomized controlled trial
INTRODUCTION: The optimal penetration of antiretroviral agents into central nervous system (CNS) may be a balance between providing adequate drug exposure to inhibit HIV-replication whilst avoiding concentrations associated with toxicities. METHODS: Cerebrospinal-fluid (CSF) exposure of efavirenz an...
Autores principales: | Winston, Alan, and Puls, Rebekah, CSF Sub-study, group Encore |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International AIDS Society
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224808/ https://www.ncbi.nlm.nih.gov/pubmed/25394049 http://dx.doi.org/10.7448/IAS.17.4.19541 |
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