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Simulation of the impact of rifampicin on darunavir/ritonavir PK and dose adjustment strategies in HIV-infected patients: a population PK approach
INTRODUCTION: Treatment of HIV/TB co-infection is challenging due to high drug–drug interaction potential between antiretrovirals and rifamycins, such as rifampicin (RIF). The PK interaction between darunavir/ritonavir (DRV/RTV) and RIF has not been studied. Utilizing other protease inhibitor data,...
Autores principales: | Dickinson, Laura, Winston, Alan, Boffito, Marta, Khoo, Saye, Back, David, Siccardi, Marco |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International AIDS Society
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224831/ https://www.ncbi.nlm.nih.gov/pubmed/25394092 http://dx.doi.org/10.7448/IAS.17.4.19586 |
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