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DRV concentrations and viral load in CSF in patients on DRV/r 600/100 or 800/100mg once daily plus two NRTI

INTRODUCTION: Darunavir/r (DRV/r) is currently used at a dose of 800/100 mg once daily (OD) in a high proportion of patients. Pharmacokinetic data suggest that 600/100 OD may be effective, reducing toxicity and cost. However, drug concentrations in reservoirs such as cerebrospinal fluid (CSF) might...

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Detalles Bibliográficos
Autores principales: Di Yacovo, Silvana, Molto, Jose, Ferrer, Elena, Curran, Adrian, Jayne Else, Laura, Clotet, Bonaventura, Tiraboschi, Juan, Niubo, Jordi, Vila, Antonia, Podzamczer, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International AIDS Society 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4225360/
https://www.ncbi.nlm.nih.gov/pubmed/25397565
http://dx.doi.org/10.7448/IAS.17.4.19821