DNA methylation reprogramming in cancer: Does it act by re-configuring the binding landscape of Polycomb repressive complexes?

DNA methylation is a repressive epigenetic mark vital for normal development. Recent studies have uncovered an unexpected role for the DNA methylome in ensuring the correct targeting of the Polycomb repressive complexes throughout the genome. Here, we discuss the implications of these findings for c...

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Detalles Bibliográficos
Autores principales: Reddington, James P, Sproul, Duncan, Meehan, Richard R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
Insights & Perspectives
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4225474/
https://www.ncbi.nlm.nih.gov/pubmed/24277643
http://dx.doi.org/10.1002/bies.201300130

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4225474/
https://www.ncbi.nlm.nih.gov/pubmed/24277643
http://dx.doi.org/10.1002/bies.201300130

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