The PHD1 finger of KDM5B recognizes unmodified H3K4 during the demethylation of histone H3K4me2/3 by KDM5B

KDM5B is a histone H3K4me2/3 demethylase. The PHD1 domain of KDM5B is critical for demethylation, but the mechanism underlying the action of this domain is unclear. In this paper, we observed that PHD1(KDM5B) interacts with unmethylated H3K4me0. Our NMR structure of PHD1(KDM5B) in complex with H3K4m...

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Detalles Bibliográficos
Autores principales: Zhang, Yan, Yang, Huirong, Guo, Xue, Rong, Naiyan, Song, Yujiao, Xu, Youwei, Lan, Wenxian, Zhang, Xu, Liu, Maili, Xu, Yanhui, Cao, Chunyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Higher Education Press 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4225485/
https://www.ncbi.nlm.nih.gov/pubmed/24952722
http://dx.doi.org/10.1007/s13238-014-0078-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4225485/
https://www.ncbi.nlm.nih.gov/pubmed/24952722
http://dx.doi.org/10.1007/s13238-014-0078-4

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