Autophagy is a critical regulator of memory CD8(+) T cell formation

During infection, CD8(+) T cells initially expand then contract, leaving a small memory pool providing long lasting immunity. While it has been described that CD8(+) T cell memory formation becomes defective in old age, the cellular mechanism is largely unknown. Autophagy is a major cellular lysosom...

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Detalles Bibliográficos
Autores principales: Puleston, Daniel J, Zhang, Hanlin, Powell, Timothy J, Lipina, Elina, Sims, Stuart, Panse, Isabel, Watson, Alexander S, Cerundolo, Vincenzo, Townsend, Alain RM, Klenerman, Paul, Simon, Anna Katharina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2014
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4225493/
https://www.ncbi.nlm.nih.gov/pubmed/25385531
http://dx.doi.org/10.7554/eLife.03706

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4225493/
https://www.ncbi.nlm.nih.gov/pubmed/25385531
http://dx.doi.org/10.7554/eLife.03706

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