Changing the peptide specificity of a human T cell receptor by directed evolution

Binding of a T cell receptor (TCR) to a peptide/major histocompatibility complex is the key interaction involved in antigen specificity of T cells. The recognition involves up to six complementarity determining regions (CDR) of the TCR. Efforts to examine the structural basis of these interactions a...

Descripción completa

Detalles Bibliográficos
Autores principales: Smith, Sheena N., Wang, Yuhang, Baylon, Javier L., Singh, Nishant K., Baker, Brian M., Tajkhorshid, Emad, Kranz, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4225554/
https://www.ncbi.nlm.nih.gov/pubmed/25376839
http://dx.doi.org/10.1038/ncomms6223

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4225554/
https://www.ncbi.nlm.nih.gov/pubmed/25376839
http://dx.doi.org/10.1038/ncomms6223

Ejemplares similares