Identification of novel tyrosine kinase inhibitors for drug resistant T315I mutant BCR-ABL: a virtual screening and molecular dynamics simulations study

BCR-ABL tyrosine kinase plays a major role in the pathogenesis of chronic myeloid leukemia (CML) and is a proven target for drug development. Currently available drugs in the market are effective against CML; however, side-effects and drug-resistant mutations in BCR-ABL limit their full potential. U...

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Detalles Bibliográficos
Autores principales: Banavath, Hemanth Naick, Sharma, Om Prakash, Kumar, Muthuvel Suresh, Baskaran, R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4225644/
https://www.ncbi.nlm.nih.gov/pubmed/25382104
http://dx.doi.org/10.1038/srep06948

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4225644/
https://www.ncbi.nlm.nih.gov/pubmed/25382104
http://dx.doi.org/10.1038/srep06948

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