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Identification of novel tyrosine kinase inhibitors for drug resistant T315I mutant BCR-ABL: a virtual screening and molecular dynamics simulations study

BCR-ABL tyrosine kinase plays a major role in the pathogenesis of chronic myeloid leukemia (CML) and is a proven target for drug development. Currently available drugs in the market are effective against CML; however, side-effects and drug-resistant mutations in BCR-ABL limit their full potential. U...

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Detalles Bibliográficos
Autores principales:	Banavath, Hemanth Naick, Sharma, Om Prakash, Kumar, Muthuvel Suresh, Baskaran, R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4225644/ https://www.ncbi.nlm.nih.gov/pubmed/25382104 http://dx.doi.org/10.1038/srep06948

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