Cargando…

The Wilms' Tumor Gene WT1 − 17AA/− KTS Splice Variant Increases Tumorigenic Activity Through Up-Regulation of Vascular Endothelial Growth Factor in an In Vivo Ovarian Cancer Model

The Wilms' tumor 1 gene WT1 encodes a zinc transcription factor involved in a variety of cancer-related processes. In this study, we sought to investigate the effects of WT1 splice variants on tumorigenic activity and survival in an in vivo ovarian cancer model. To this end, we established stab...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yamanouchi, Keiko, Ohta, Tsuyoshi, Liu, Zhiyang, Oji, Yusuke, Sugiyama, Haruo, Shridhar, Viji, Matsumura, Sohei, Takahashi, Toshifumi, Takahashi, Kazuhiro, Kurachi, Hirohisa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Neoplasia Press 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4225694/ https://www.ncbi.nlm.nih.gov/pubmed/25389453 http://dx.doi.org/10.1016/j.tranon.2014.07.008

Ejemplares similares

Molecular mechanism of Wilms’ tumor (Wt1) (+/−KTS) variants promoting proliferation and migration of ovarian epithelial cells by bioinformatics analysis
por: Wang, Xiaomei, et al.
Publicado: (2023)

A New Role for Wilms Tumor Protein 1: Differential Activities of + KTS and –KTS Variants to Regulate LHβ Transcription
por: Bagchi, Debalina, et al.
Publicado: (2015)

The -KTS splice variant of WT1 is essential for ovarian determination in mice
por: Gregoire, Elodie P, et al.
Publicado: (2023)

Expression of the Wilms' Tumor Gene WT1 in Solid Tumors and Its Involvement in Tumor Cell Growth
por: Oji, Yusuke, et al.
Publicado: (1999)

IMT-07 CLINICAL TRIAL OF A COCKTAIL WILMS’ TUMOR 1 (WT1) VACCINATION USING TWO HLA CLASS I PEPTIDES AND ONE CLASS II PEPTIDE FOR RECURRENT MALIGNANT GLIOMAS
por: Kagawa, Naoki, et al.
Publicado: (2019)

Wilms Tumor Gene (WT1) Peptide–based Cancer Vaccine Combined With Gemcitabine for Patients With Advanced Pancreatic Cancer
por: Nishida, Sumiyuki, et al.
Publicado: (2014)

A phase I clinical study of a cocktail vaccine of Wilms’ tumor 1 (WT1) HLA class I and II peptides for recurrent malignant glioma
por: Tsuboi, Akihiro, et al.
Publicado: (2018)

Identification of a Novel C-Terminal Truncated WT1 Isoform with Antagonistic Effects against Major WT1 Isoforms
por: Tatsumi, Naoya, et al.
Publicado: (2015)

The Wilms’ tumor (WT1) gene: Methods and protocols
por: Agrawal, Suraksha
Publicado: (2018)

A 46,XY Female DSD Patient with Bilateral Gonadoblastoma, a Novel SRY Missense Mutation Combined with a WT1 KTS Splice-Site Mutation
por: Hersmus, Remko, et al.
Publicado: (2012)

Wilms’ Tumour gene 1 (WT1) as an immunotherapeutic target
por: Coosemans, A.
Publicado: (2011)

Wilms Tumor-1 (WT1) rs16754 Polymorphism
por: Sookaromdee, Pathum, et al.
Publicado: (2019)

Implications of the Wilms’ Tumor Suppressor Wt1 in Cardiomyocyte Differentiation
por: Wagner, Nicole, et al.
Publicado: (2021)

The First Snake Venom KTS/Disintegrins-Integrin Interactions Using Bioinformatics Approaches
por: Khamessi, Oussema, et al.
Publicado: (2022)

Extremely strong infiltration of WT1-specific CTLs into mouse tumor by the combination vaccine with WT1-specific CTL and helper peptides
por: Nakata, Jun, et al.
Publicado: (2018)

Prognostic significance of specific anti-WT1 IgG antibody level in plasma in patients with ovarian carcinoma
por: Andersson, Charlotta, et al.
Publicado: (2014)

WT1 Peptide Cancer Vaccine for Patients with Hematopoietic Malignancies and Solid Cancers
por: Oka, Yoshihiro, et al.
Publicado: (2007)

Chemotherapy and terminal skeletal muscle differentiation in WT1‐mutant Wilms tumors
por: Royer‐Pokora, Brigitte, et al.
Publicado: (2018)

Every Beat You Take—The Wilms′ Tumor Suppressor WT1 and the Heart
por: Wagner, Nicole, et al.
Publicado: (2021)

Association of WT1 IgG antibody against WT1 peptide with prolonged survival in glioblastoma multiforme patients vaccinated with WT1 peptide
por: Oji, Yusuke, et al.
Publicado: (2016)

A high incidence of WT1 abnormality in bilateral Wilms tumours in Japan, and the penetrance rates in children with WT1 germline mutation
por: Kaneko, Y, et al.
Publicado: (2015)

TSA downregulates Wilms tumor gene 1 (Wt1) expression at multiple levels
por: Makki, Mohammad Shahidul, et al.
Publicado: (2008)

Studies of Wilms’ Tumor (WT1) Gene Expression in Adult Acute Leukemias in Singapore
por: Lim, Che Kang, et al.
Publicado: (2007)

Nephron, Wilms’ tumor-1 (WT1), and synaptopodin expression in developing podocytes of mice
por: Kato, Takashi, et al.
Publicado: (2017)

The Wilms tumor protein Wt1 contributes to female fertility by regulating oviductal proteostasis
por: Nathan, Abinaya, et al.
Publicado: (2017)

Pioglitazone counteracts the tumor necrosis factor-α inhibition of follicle-stimulating hormone-induced follicular development and estradiol production in an in vitro mouse preantral follicle culture system
por: Hara, Shuichiro, et al.
Publicado: (2013)

Design of an Optimized Wilms' Tumor 1 (WT1) mRNA Construct for Enhanced WT1 Expression and Improved Immunogenicity In Vitro and In Vivo
por: Benteyn, Daphné, et al.
Publicado: (2013)

Diagnostic utility of Wilms’ tumour-1 protein (WT-1) immunostaining in paediatric renal tumours
por: Goyal, Surbhi, et al.
Publicado: (2016)

Comprehensive Biology and Genetics Compendium of Wilms Tumor Cell Lines with Different WT1 Mutations
por: Royer-Pokora, Brigitte, et al.
Publicado: (2020)

TERT Expression in Wilms Tumor Is Regulated by Promoter Mutation or Hypermethylation, WT1, and N-MYC
por: Jablonowski, Carolyn M., et al.
Publicado: (2022)

Long-term kidney function in children with Wilms tumour and constitutional WT1 pathogenic variant
por: Falcone, Maria Pia, et al.
Publicado: (2021)

WT1 epitope-specific IgG and IgM antibodies for immune-monitoring in patients with advanced sarcoma treated with a WT1 peptide cancer vaccine
por: Alzaaqi, Shouq, et al.
Publicado: (2022)

Mutation or loss of Wilms' tumor gene 1 (WT1) are not major reasons for immune escape in patients with AML receiving WT1 peptide vaccination
por: Busse, Antonia, et al.
Publicado: (2010)

Wilms’ Tumour 1 (WT1) peptide vaccination in patients with acute myeloid leukaemia induces short-lived WT1-specific immune responses
por: Uttenthal, Benjamin, et al.
Publicado: (2014)

Dysregulation of WTI (−KTS) is Associated with the Kidney-Specific Effects of the LMX1B R246Q Mutation
por: Hall, Gentzon, et al.
Publicado: (2017)

Brachial-to-ankle pulse wave velocity as an independent prognostic factor for ovulatory response to clomiphene citrate in women with polycystic ovary syndrome
por: Takahashi, Toshifumi, et al.
Publicado: (2014)

Evidence for susceptibility genes to familial Wilms tumour in addition to WT1, FWT1 and FWT2
por: Rapley, E A, et al.
Publicado: (2000)

The Wilms' Tumor Suppressor Protein WT1 Is Processed by the Serine Protease HtrA2/Omi
por: Hartkamp, Jörg, et al.
Publicado: (2010)

The Wilms’ tumor gene (WT1) regulates E-cadherin expression and migration of prostate cancer cells
por: Brett, Adina, et al.
Publicado: (2013)

Deducing the stage of origin of Wilms' tumours from a developmental series of Wt1-mutant mice
por: Berry, Rachel L., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_j3ofcr2k87go5pukmpn2876966