Omega 3 fatty acids chemosensitize multidrug resistant colon cancer cells by down-regulating cholesterol synthesis and altering detergent resistant membranes composition

BACKGROUND: The activity of P-glycoprotein (Pgp) and multidrug resistance related protein 1 (MRP1), two membrane transporters involved in multidrug resistance of colon cancer, is increased by high amounts of cholesterol in plasma membrane and detergent resistant membranes (DRMs). It has never been i...

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Detalles Bibliográficos
Autores principales: Gelsomino, Giada, Corsetto, Paola A, Campia, Ivana, Montorfano, Gigliola, Kopecka, Joanna, Castella, Barbara, Gazzano, Elena, Ghigo, Dario, Rizzo, Angela M, Riganti, Chiara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4225767/
https://www.ncbi.nlm.nih.gov/pubmed/24225025
http://dx.doi.org/10.1186/1476-4598-12-137

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4225767/
https://www.ncbi.nlm.nih.gov/pubmed/24225025
http://dx.doi.org/10.1186/1476-4598-12-137

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