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Proton Release from the Histidine-Tetrad in the M2 Channel of the Influenza A Virus
[Image: see text] The activity of the M2 proton channel of the influenza A virus is controlled by pH. The tautomeric state and conformation of His37, a key residue in the M2 transmembrane four-helix bundle, controls the gating of the channel. Previously, we compared the energetics and dynamics of tw...
Autores principales: | Dong, Hao, Fiorin, Giacomo, DeGrado, William F., Klein, Michael L. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society
2014
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226308/ https://www.ncbi.nlm.nih.gov/pubmed/25317959 http://dx.doi.org/10.1021/jp5102225 |
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