The CB1 cannabinoid receptor agonist reduces L-DOPA-induced motor fluctuation and ERK1/2 phosphorylation in 6-OHDA-lesioned rats

The dopamine precursor L-3,4-dihydroxyphenylalanine (L-DOPA) has been used as an effective drug for treating dopamine depletion-induced Parkinson’s disease (PD). However, long-term administration of L-DOPA produces motor complications. L-DOPA has also been found to modify the two key signaling casca...

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Detalles Bibliográficos
Autores principales: Song, Lu, Yang, Xinxin, Ma, Yaping, Wu, Na, Liu, Zhenguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226453/
https://www.ncbi.nlm.nih.gov/pubmed/25395834
http://dx.doi.org/10.2147/DDDT.S60944

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226453/
https://www.ncbi.nlm.nih.gov/pubmed/25395834
http://dx.doi.org/10.2147/DDDT.S60944

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