Regulatory roles of LINE-1-encoded reverse transcriptase in cancer onset and progression

LINE-1 retrotransposons encode the reverse transcriptase (RT) enzyme, required for their own mobility, the expression of which is inhibited in differentiated tissues while being active in tumors. Experimental evidence indicate that the inhibition of LINE-1-derived RT restores differentiation in canc...

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Detalles Bibliográficos
Autores principales: Sciamanna, Ilaria, Gualtieri, Alberto, Piazza, Pier Vincenzo, Spadafora, Corrado
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226666/
https://www.ncbi.nlm.nih.gov/pubmed/25478632

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226666/
https://www.ncbi.nlm.nih.gov/pubmed/25478632

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