Anti-cancer potency of tasquinimod is enhanced via albumin-binding facilitating increased uptake in the tumor microenvironment

Tasquinimod, an orally active quinoline-3-carboxamide, binds with high affinity to HDAC4 and S100A9 in cancer and infiltrating host cells within compromised tumor microenvironment inhibiting adaptive survival pathways needed for an angiogenic response. Clinical trials document that as low as 0.5-1mg...

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Detalles Bibliográficos
Autores principales: Isaacs, John T., Dalrymple, Susan L., Rosen, D. Marc, Hammers, Hans, Olsson, Anders, Leanderson, Tomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226669/
https://www.ncbi.nlm.nih.gov/pubmed/25193858

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226669/
https://www.ncbi.nlm.nih.gov/pubmed/25193858

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