Tissue-specific isoform switch and DNA hypomethylation of the pyruvate kinase PKM gene in human cancers

The M2 isoform of pyruvate kinase (PKM2) plays an important role in aerobic glycolysis and is a mediator of the Warburg effect in tumors. It was previously thought that tumor cells switch expression of PKM from normal tissue-expressed PKM1 to tumor-specific PKM2 via an alternative splicing mechanism...

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Detalles Bibliográficos
Autores principales: Desai, Shruti, Ding, Minming, Wang, Bin, Lu, Zhimin, Zhao, Qi, Shaw, Kenna, Yung, W.K. Alfred, Weinstein, John N., Tan, Ming, Yao, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2013
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226677/
https://www.ncbi.nlm.nih.gov/pubmed/24077665

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226677/
https://www.ncbi.nlm.nih.gov/pubmed/24077665

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