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Feedback activation of STAT3 mediates trastuzumab resistance via upregulation of MUC1 and MUC4 expression
Although HER2-targeting antibody trastuzumab confers a substantial benefit for patients with HER2-overexpressing breast and gastric cancer, overcoming trastuzumab resistance remains a large unmet need. In this study, we revealed a STAT3-centered positive feedback loop that mediates the resistance of...
| Autori principali: | , , , , , , , , , |
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| Natura: | Online Articolo testo |
| Lingua: | English |
| Pubblicazione: |
Impact Journals LLC
2014
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| Soggetti: | |
| Accesso online: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226685/ https://www.ncbi.nlm.nih.gov/pubmed/25327561 |