Feedback activation of STAT3 mediates trastuzumab resistance via upregulation of MUC1 and MUC4 expression

Although HER2-targeting antibody trastuzumab confers a substantial benefit for patients with HER2-overexpressing breast and gastric cancer, overcoming trastuzumab resistance remains a large unmet need. In this study, we revealed a STAT3-centered positive feedback loop that mediates the resistance of...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Guangchao, Zhao, Likun, Li, Wei, Fan, Kexing, Qian, Weizhu, Hou, Sheng, Wang, Hao, Dai, Jianxin, Wei, Huafeng, Guo, Yajun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226685/
https://www.ncbi.nlm.nih.gov/pubmed/25327561

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226685/
https://www.ncbi.nlm.nih.gov/pubmed/25327561

Ejemplares similares