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Feedback activation of STAT3 mediates trastuzumab resistance via upregulation of MUC1 and MUC4 expression
Although HER2-targeting antibody trastuzumab confers a substantial benefit for patients with HER2-overexpressing breast and gastric cancer, overcoming trastuzumab resistance remains a large unmet need. In this study, we revealed a STAT3-centered positive feedback loop that mediates the resistance of...
Autores principales: | Li, Guangchao, Zhao, Likun, Li, Wei, Fan, Kexing, Qian, Weizhu, Hou, Sheng, Wang, Hao, Dai, Jianxin, Wei, Huafeng, Guo, Yajun |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226685/ https://www.ncbi.nlm.nih.gov/pubmed/25327561 |
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