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A spatial simulation approach to account for protein structure when identifying non-random somatic mutations
BACKGROUND: Current research suggests that a small set of “driver” mutations are responsible for tumorigenesis while a larger body of “passenger” mutations occur in the tumor but do not progress the disease. Due to recent pharmacological successes in treating cancers caused by driver mutations, a va...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227039/ https://www.ncbi.nlm.nih.gov/pubmed/24990767 http://dx.doi.org/10.1186/1471-2105-15-231 |